Euan Joly-Smith

Euan Joly-Smith

Postdoctoral Researcher

van Oudenaarden group

Hubrecht Institute

A theoretical physicist with a habit of doing experiments in biology.

I am trained in many mathematical disciplines including stochastic processes, information theory, and computational modelling. My experimental skills include cloning synthetic gene circuits in bacteria, time-lapse fluorescence microscopy, using microfluidic devices, and applying machine learning algorithms for cell segmentation.

My main contributions are generalized constraints that characterize entire classes of systems modelling biochemical reaction networks in cells. These constraints can be exploited with gene expression reporters to detect causal and dynamic properties of gene regulatory networks from population snapshots of gene expression variability. I transitioned to the alluring world of experimental biology and engineered many variants of the celebrated Repressilator gene circuit to turn theory into practice.

I am always excited to share my research in person or via zoom, and fortunate to have given talks at conferences and groups located in Hawaii, Chicago, Las Vegas, Dresden, Manchester, and Montréal.

I obtained a BSc. in Honours Physics and Mathematics from McGill University in 2017, a MSc. in Physics from the University of Toronto in 2019, and a PhD in Physics from the University of Toronto in 2024 advised by Andreas Hilfinger. Currently I am a postdoc in the lab of Alexander van Oudenaarden.

Publications & Preprints

(2023). Exploiting fluctuations in gene expression to detect causal interactions between genes. (bioRxiv).

PDF Link

(2023). Measuring prion propagation in single bacteria elucidates mechanism of loss. PNAS.

PDF Link

(2021). Inferring gene regulation dynamics from static snapshots of gene expression variability. PRE.

PDF Link Blog

Presentations


University of Manchester Developmental Biology Seminar, January 2024
Exploiting fluctuations in gene expression to detect causal interactions between genes.
Invited talk.

APS March Meeting, March 2023
Exploiting stochastic fluctuations in gene expression to infer interactions between genes.
Contributed talk (APS Travel Award).

Biophysique Quebec 2nd Annual Symposium, October 2022
Exploiting stochastic fluctuations in gene expression to infer interactions between genes.
Contributed talk.

Canadian Association of Physicists congress, June 2022
Inferring causality in gene regulation from static snapshots of gene expression variability.
Contributed Talk.

Annual Meeting of the Biophysical Society of Canada, May 2022
Inferring gene regulation dynamics from static snapshots of gene expression reporters.
Contributed poster presentation with talk at student symposium (BSC Best Poster Award).

Quantitative Approaches in Biology at Northwestern University, March 2022
Fluorescence maturation time: a nuisance or a feature?
Contributed lightning talk and poster presentation.

APS March Meeting, March 2022
Inferring gene regulation from static snapshots of gene expression variability.
Contributed talk.

Winter q-bio, February 2022
Inferring gene regulation from static snapshots of gene expression variability.
Contributed talk.

BiophysiQ Molecular and Cellular Biophysics Virtual Mini-Symposium, November 2021
Fluorescent maturation time: is it a bug or a feature?
Contributed talk.

BactoMontreal 2021 meeting, October 2021
Inferring gene regulation dynamics from static snapshots of gene expression variability.
Poster presentation.

EMBO workshop on Physics of Living Systems : From Molecules to Tissues, June 2021
Inferring gene regulation dynamics from static snapshots of gene expression reporters.
Contributed talk.

Annual Meeting of the Biophysical Society of Canada,May 2021
Inferring gene regulation dynamics from static snapshots of gene expression variability.
Poster presentation.

RIP Graduate Seminar at the University of Toronto Mississauga, October 2021
Inferring gene regulation dynamics from static snapshots of gene expression reporters.
Invited talk.

Canadian Association of Physicists Virtual Congress, June 2020
Characteristic variability of co-regulated genes.
Contributed talk.

Annual Meeting of the Biophysical Society of Canada, June 2019
Characteristic variability of co-regulated genes.
Poster presentation.